Phenibut is increasingly on the radar of nootropic researchers, but that begs the question: what is phenibut?
This article will give a comprehensive background of phenibut in terms that you can understand. It’ll cover not only what phenibut is, but what it’s made from, what it’s used for, and the difference between phenibut HCL and phenibut FAA.
Let’s get to it.
Order Phenibut online from the best vendor in the world!
Great prices, quick shipping, and guaranteed delivery.
Disclaimer: Phenibut.com contains information about products that are intended for laboratory and research use only, unless otherwise explicitly stated. This information, including any referenced scientific or clinical research, is made available for educational purposes only. Phenibut.com makes every effort to ensure that any information it shares complies with national and international standards for clinical trial information and is committed to the timely disclosure of the design and results of all interventional clinical studies for innovative treatments publicly available or that may be made available. However, research is not considered conclusive. Phenibut.com makes no claims that any products referenced can cure, treat or prevent any conditions, including any conditions referenced on its website or in print materials.
What is Phenibut?
Phenibut is a GABA analogue that can affect mood and well-being. The name “phenibut” comes from its chemical name: β‐phenyl‐γ‐aminobutyric acid. You may also see it called by various prescription medication brand names, including Anvifen, Fenibut, and Noofen.
Phenibut, chemically, is an amino acid . That’s a fancy way of saying that phenibut is an organic compound that contains both an “amine” (–NH2) group and a “carboxyl” (–COOH) group. If you’re not a chem major, don’t worry—it’s basically made of the same kinds of molecules that make proteins, except it’s not as long as a protein.
The particular structure of this amino acid makes it a psychoactive drug, which means that it has an effect on the mental state of the person ingesting it.
Phenibut mimics GABA
Phenibut affects the user’s mental state in a few ways. The primary way is by mimicking one of the neurotransmitters that’s present in the nervous system: GABA .
Neurotransmitters play an important role in helping messages get sent from one nerve cell to the next. Some neurotransmitters are excitatory; they increase the firing of nerve cells.
GABA is an inhibitory neurotransmitter, which means that it reduces the firing of nerve cells. This sounds like it’s not a big deal, but it’s actually really important. Imagine your brain is a car: Sometimes you want to hit the gas so you can go quickly. But sometimes you need to brake. In that car metaphor, GABA is a chemical that helps with braking. It gives you the chance to slow down and rest.
Since phenibut is chemically similar to GABA, it’s called a “GABA analogue” and has a similar effect as GABA does. Phenibut is able to bind to some of the GABA receptors that you have throughout your body , acting as an inhibitory agent. The result is that it can calm the human subject’s brain, reduce stress, lower anxiety, and aid sleep [1, 3].
Phenibut and Other Neurotransmitters
Phenibut doesn’t just work on the GABA pathway, but it also seems to mildly upregulate dopamine in the brain .
Dopamine is another neurotransmitter. It’s a bit complex and performs quite a few different tasks, but it’s associated with mood: higher dopamine levels tend to create feelings of happiness and well-being.
That’s part of the reason phenibut may have mood-boosting effects.
What Is Phenibut Made From?
We know that it’s an amino acid, but what is phenibut made from?
In general, making amino acids involves complex chemistry . One way to make phenibut  entails an eight-step process involving benzaldehyde, dimethylmalonic ether, dicarboxylic acid, acetic anhydride, and sodium hypobromide.
As a final product, phenibut typically comes in two different forms: phenibut HCL and FAA.
Phenibut HCL is the most common form of phenibut. If you search to buy phenibut online, this is likely the form you’ll come across.
So what is phenibut HCL? It is basically just the phenibut molecule with an extra molecule comprised of hydrogen and chlorine on the end. As it’s being synthesized, the HCL attaches to the phenibut molecule. This doesn’t affect how phenibut works in the body, but it does change what it looks like and how it should be taken.
When phenibut is attached to the HCL, it forms an ionic salt. That matters because ionic salts break up easily in water to form a solution. That means that this form of phenibut is easily dissolved in water and can be drunk. The salt also explains why this form of phenibut looks more like crystals than powder.
But don’t worry: It’s not table salt, and it won’t taste salty for your research subjects.
Here’s a quick summary of the characteristics of phenibut HCL as compared to FAA:
- It tends to be a bit cheaper;
- You need a slightly larger dose to get the same effect;
- You can dissolve it in liquids;
- You usually take it in a pill capsule or in a drink;
- It’s too acidic to take sublingually.
Okay, so then what is phenibut FAA?
The “FAA” stands for “Free Amino Acid.” This form of phenibut is basically just pure phenibut without an additional HCL group or anything else.
What that means for you is that it doesn’t look like crystals, but rather like a fine powder. Because it’s not an ionic salt, it doesn’t dissolve easily in water or other liquid. That means it’s harder to take in drinks.
Here’s a quick summary about phenibut FAA and how it’s different from phenibut HCL:
- It’s usually a little more expensive;
- It usually requires a slightly smaller dose;
- It doesn’t dissolve, so it’s not as easy to take it in a drink;
- Instead, it’s best to take it in a capsule or let it dissolve under the tongue;
- It’s not acidic, so if it dissolves under the subject’s tongue, it won’t wreck their teeth.
What Is Phenibut Used For?
Phenibut has been used for decades in several countries as a pharmaceutical medication. There’s significant evidence that it has a variety of effects.
- Insomnia [7, 8, 9]
- Anxiety [10, 11]
- Vestibular disorders
- Alcoholism and alcohol withdrawal syndrome
- Motion sickness
In the United States, however, phenibut is an unapproved “New Drug” under the U.S. Federal Food, Drug, and Cosmetic Act (FD&C Act), and has not been investigated or approved for any of the above uses.
The recreational use of phenibut has been documented both anecdotally and in the literature .
Phenibut Side Effects and Safety
So phenibut potentially has several effects … but is it safe to administer to human subjects?
We have a comprehensive guide to phenibut side effects and safety and another one on phenibut withdrawal. But we’ll go over potential concerns briefly here as well, so you know what you might be getting into if you pursue research on phenibut.
Basically, there are three different categories of risk with phenibut:
- There are side effects and allergies (that are uncommon, but can affect anyone);
- There are potential interaction effects (which only affect research subjects if they mix phenibut with other substances); and,
- There are potential withdrawal effects (which only affect research subjects that develop a physical dependence on phenibut).
Let’s look at these in turn…
Side effects and allergies
If human subjects are allergic to phenibut, they might also experience rashes or itching.
The other thing that researchers need to be aware of is not to mix phenibut with anything that it could interact with. Because phenibut depresses and slows down the nervous system, it shouldn’t be taken with other substances that do the same thing . And, since it works by upregulating GABA, it’s best not to take it with other medications that increase GABA levels.
If it's taken with other nervous system depressants or GABA agonists, there’s a risk that test subjects may experience exacerbated or extended effects of either or both substances. According to the U.S. Centers for Disease Control and Prevention (CDC), there has been at least one reported death among exposures in which phenibut was the only drug or agent involved .
- Antipsychotic medications
- Sedatives or sleeping pills
- Anti-anxiety medications
Ensure your subjects know not to mix phenibut and any of those medications and substances.
- Rebound anxiety
- Reduced level of consciousness
- Auditory and visual hallucinations
You can help reduce the risk that your test subjects experience withdrawal symptoms by developing a study protocol that limits both the size and the frequency of phenibut doses. One precaution is to design your research study so that subjects take phenibut a maximum of 1-2 times per week.
Where To Buy Phenibut Online | 2021 Guide
If you want to purchase this research nootropic, your best bet is to get it from a reliable online vendor.
So where can you get it? Science.bio.
This is the only vendor we trust to provide a high-quality product at a reasonable price. Here’s a quick review of their benefits:
- Convenient, safe payment options
- Great return policy
- Real customer service people
- Excellent product with reasonable prices
- Certificate of analysis to show purity
They’re great and they’re not going to rip you off. Highly recommended.
Ready to order Phenibut from the top-rated online vendor?
What Is Phenibut? | Verdict
Phenibut is a very promising research nootropic and we have a lot more to learn about it. It’s technically an amino acid that mimics GABA and boosts dopamine, which is presumably how it has its purported effects.
What is phenibut used for?
There’s evidence that phenibut makes human subjects feel less anxious, experience boosted mood, and have enhanced cognition—at least in some study populations in certain contexts.
But there continues to be some uncertainty about its effects, which is why more research on this potentially powerful nootropic is a step in the right direction.